CD8(+) Tregs revisited: A heterogeneous population with different phenotypes and properties
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00544971" target="_blank" >RIV/68378050:_____/21:00544971 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/21:10438694
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/eji.202048614" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/eji.202048614</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/eji.202048614" target="_blank" >10.1002/eji.202048614</a>
Alternative languages
Result language
angličtina
Original language name
CD8(+) Tregs revisited: A heterogeneous population with different phenotypes and properties
Original language description
Regulatory T cells (Tregs) play a key role in the peripheral self-tolerance and preventing autoimmunity. While classical CD4(+) Foxp3(+) Tregs are well established, their CD8(+) counterparts are still controversial in many aspects including their phenotypic identity and their mechanisms of suppression. Because of these controversies and because of only a limited number of studies documenting the immunoregulatory function of CD8(+) Tregs in vivo, the concept of CD8(+) Tregs is still not unanimously accepted. We propose that any T-cell subset considered as true regulatory must be distinguishable from other cell types and must suppress in vivo immune responses via a known mechanism. In this article, we revisit the concept of CD8(+) Tregs by focusing on the characterization of individual CD8(+) T-cell subsets with proposed regulatory capacity separately. Therefore, we review the phenotype and function of CD8(+) FOXP3(+) T cells, CD8(+) CD122(+) T cells, CD8(+) CD28(low/-) T cells, CD8(+) CD45RC(low) T cells, T cells expressing CD8 alpha alpha homodimer and Qa-1-restricted CD8(+) T cells to show whether there is sufficient evidence to establish these subsets as bona fide Tregs. Based on the intrinsic ability of CD8(+) Treg subsets to promote immune tolerance in animal models, we elaborate on their potential use in clinics.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/GJ19-03435Y" target="_blank" >GJ19-03435Y: Naïve, memory, and virtual memory T cells in adaptive immune responses</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Immunology
ISSN
0014-2980
e-ISSN
1521-4141
Volume of the periodical
51
Issue of the periodical within the volume
3
Country of publishing house
DE - GERMANY
Number of pages
19
Pages from-to
512-530
UT code for WoS article
000619568300001
EID of the result in the Scopus database
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