Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00057825" target="_blank" >RIV/00216224:14110/12:00057825 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/12:#0001971

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0047077" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0047077</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0047077" target="_blank" >10.1371/journal.pone.0047077</a>

Result language

angličtina

Original language name

Increased T regulatory cells are associated with adverse clinical features and predict progression in multiple myeloma.

Original language description

Background: Regulatory T (Treg) cells play an important role in the maintenance of immune system homeostasis. Multiple myeloma (MM) is a plasma cell disorder frequently associated with impaired immune cell numbers and functions. Methods: We analyzed Tregcells in peripheral blood (n = 207) and bone marrow (n = 202) of pre-malignant and malignant MM patients using flow cytometry. Treg cells and their subsets from MM patients and healthy volunteers were functionally evaluated for their suppressive property. A cohort of 25 patients was analyzed for lymphocytes, CD4 T cells and Treg cells before and after treatment with cyclophosphamide, thalidomide plus dexamethasone (CTD). Results: We found elevated frequencies of Treg cells in newly diagnosed (P&lt;0.01) and relapsed MM patients (P&lt;0.0001) compared to healthy volunteers. Also, Treg subsets including naive (P = 0.015) and activated (P = 0.036) Treg cells were significantly increased in MM patients compared to healthy volunteers.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS One

ISSN

1932-6203

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

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UT code for WoS article

000312385200077

EID of the result in the Scopus database

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