Genetic polymorphisms and MicroRNAs: new direction in molecular epidemiology of solid cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059147" target="_blank" >RIV/00216224:14110/12:00059147 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/12:#0000339
Result on the web
<a href="http://dx.doi.org/10.1111/j.1582-4934.2011.01359.x" target="_blank" >http://dx.doi.org/10.1111/j.1582-4934.2011.01359.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1582-4934.2011.01359.x" target="_blank" >10.1111/j.1582-4934.2011.01359.x</a>
Alternative languages
Result language
angličtina
Original language name
Genetic polymorphisms and MicroRNAs: new direction in molecular epidemiology of solid cancer
Original language description
MicroRNAs (miRNAs) are small non-coding RNAs which regulate gene expression. Single nucleotide polymorphisms (SNPs) may occur in miRNA biogenesis pathway genes, pri-miRNA, pre-miRNA or a mature miRNA sequence. Such polymorphisms may be functional with respect to biogenesis and actions of mature miRNA. Specific SNPs were identified in predicted miRNA target sites within 3' untranslated regions of mRNAs. These SNPs have a potential to affect the efficiency of miRNA binding to the target sites or can create or disrupt binding sites. Resulting gene dysregulation may involve changes in phenotype and may eventually prove critical for the susceptibility to cancer and its onset as well as for estimates of prognosis and therapy response. In this review, we provide a comprehensive list of potentially functional miRNA-related SNPs and summarize their importance as candidate cancer biomarkers.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Cellular and Molecular Medicine
ISSN
1582-1838
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
8-21
UT code for WoS article
000298586600002
EID of the result in the Scopus database
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