Polymorphisms in miRNA-binding sites of nucleotide excision repair genes and colorectal cancer risk

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11927" target="_blank" >RIV/00216208:11110/12:11927 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/12:00379749 RIV/00064190:_____/12:#0000303 RIV/00064165:_____/12:11927

Result on the web

<a href="http://dx.doi.org/10.1093/carcin/bgs172" target="_blank" >http://dx.doi.org/10.1093/carcin/bgs172</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Polymorphisms in miRNA-binding sites of nucleotide excision repair genes and colorectal cancer risk

Original language description

Reduced DNA repair capacity and DNA damage accumulation may lead to cancer development. Regulation of and coordination between genes involved in DNA repair pathways is fundamental for maintaining genome stability, and post-transcriptional gene regulationby microRNAs (miRNAs) may therefore be of particular relevance. In this context, the presence of single nucleotide polymorphisms (SNPs) within the 3' untranslated regions of target DNA repair genes could alter the binding with specific miRNAs, modulating gene expression and ultimately affecting cancer susceptibility. In this study, we investigated the role of genetic variations in miRNA-binding sites of nucleotide excision repair (NER) genes in association with colorectal cancer (CRC) risk. From 28 NERgenes, we screened among SNPs residing in their 3' untranslated regions and simultaneously located in miRNA-binding sites, with an in silico approach. Through the calculation of different binding free energy according to both alleles of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carcinogenesis

ISSN

0143-3334

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

1346-1351

UT code for WoS article

000306925600013

EID of the result in the Scopus database

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