Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059784" target="_blank" >RIV/00216224:14110/12:00059784 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16170/12:43871607 RIV/62157124:16810/12:43871708 RIV/60460709:41210/12:54885 RIV/62156489:43210/12:00187192

Result on the web

<a href="http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x" target="_blank" >http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1399-0039.2011.01827.x" target="_blank" >10.1111/j.1399-0039.2011.01827.x</a>

Result language

angličtina

Original language name

Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Original language description

Melanoma is a common disease occurring in many horse breeds. As in all tumors its nature is complex, and specific genes were shown to be involved in the mechanisms of disease in humans as well as in various animal species (1). Grey horses, regardless ofthe breed, show high incidence of dermal melanomas. A mutation within the syntaxin 17 gene responsible for greying in horses was shown to be associated with occurrence of melanoma in grey horses but the association observed did not explain completely thevariation observed (2). Other factors influencing the formation of melanoma thus must be involved. In this context, immunity-related genes can be considered as functional candidate genes. Old Kladruber grey horses were selected as a model for analyzingassociations between microsatellite and candidate gene polymorphic markers and the presence of melanoma. Genetic diversity of this old, small, isolated and partially inbred population was characterized previously.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Tissue Antigens

ISSN

0001-2815

e-ISSN

—

Volume of the periodical

79

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

2

Pages from-to

247-248

UT code for WoS article

000300978800003

EID of the result in the Scopus database

—