Apolipoprotein E Polymorphism Is Associated with Both Number of Diseased Vessels and Extent of Coronary Artery Disease in Czech Patients with CAD

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059806" target="_blank" >RIV/00216224:14110/12:00059806 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/12:#0000849

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2012.051" target="_blank" >http://dx.doi.org/10.5507/bp.2012.051</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2012.051" target="_blank" >10.5507/bp.2012.051</a>

Result language

angličtina

Original language name

Apolipoprotein E Polymorphism Is Associated with Both Number of Diseased Vessels and Extent of Coronary Artery Disease in Czech Patients with CAD

Original language description

Aims. The impact of ApoE polymorphism on angiographic parameters was assessed in patients referred for coronary angiography. Methods. Elective coronary angiography was performed in 671 subjects (525 men, 146 women, mean age 60+/-10 years) with symptoms of ischemic heart disease. The patients were divided into: no CAD group (smooth coronary vessels, n=83), one-vessel (n=155), two-vessel (n=170) and three-vessel disease (n=196). Patients with stenoses 0-50% were excluded. Within patients with CAD, we evaluated overall extent of CAD measured by the number of stenotic segments according to AHA (1 segment vs. 2?3 vs. more than 4), and the severity of the most serious stenosis (in percent). ApoE genotype was determined using real-time PCR. Results. The frequency of epsilon2/epsilon3 genotype (n=56) was lower in the three-vessel disease group compared to one-vessel disease (OR=0.25, P=0.0019), two-vessel disease (OR=0.31, P=0.0114) or no CAD group (OR=0.24, P=0.0057).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

156

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

8

Pages from-to

151-158

UT code for WoS article

000306401700010

EID of the result in the Scopus database

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