Spectrometric and Electrochemical Analysis of Sarcosine as a Potential Prostate Carcinoma Marker

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059961" target="_blank" >RIV/00216224:14110/12:00059961 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/12:00187242 RIV/00216305:26620/12:PU98520
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Spectrometric and Electrochemical Analysis of Sarcosine as a Potential Prostate Carcinoma Marker
Original language description
Sarcosine, also known as N-methylglycine, is a natural ubiquitous non/protein amino acid which occurs as intermediate and side product in glycine synthesis and degradation. Recently, sarcosine has been investigated as a new putative marker in relation toprostate cancer. Sarcosine was identified as a differential metabolite that was greatly increased during prostate cancer progression to metastasis and could be detected in urine. It was also shown, that sarcosine addition to benign prostate cell cultures caused increase of their invasivity and motility. The aim of our study was to propose a low-cost, robust and simple method suitable for sarcosine determination in biological samples such as urine or blood plasma. For this purpose an ion exchange liquidchromatography as robust separation method was tested however this method suffers from insufficient limit of detection at the level of 70 microM of sarcosine.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CG - Electrochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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