Thalidomide versus dexamethasone for the treatment of relapsed and/or refractory multiple myeloma: results from OPTIMUM, a randomized trial

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00061480" target="_blank" >RIV/00216224:14110/12:00061480 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/12:#0001844

Result on the web

<a href="http://dx.doi.org/10.3324/haematol.2011.044271" target="_blank" >http://dx.doi.org/10.3324/haematol.2011.044271</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3324/haematol.2011.044271" target="_blank" >10.3324/haematol.2011.044271</a>

Result language

angličtina

Original language name

Thalidomide versus dexamethasone for the treatment of relapsed and/or refractory multiple myeloma: results from OPTIMUM, a randomized trial

Original language description

Background Thalidomide has potent antimyeloma activity, but no prospective, randomized controlled trial has evaluated thalidomide monotherapy in patients with relapsed/refractory multiple myeloma. Design and Methods We conducted an international, randomized, open-label, four-arm, phase III trial to compare three different doses of thalidomide (100, 200, or 400 mg/day) with standard dexamethasone in patients who had received one to three prior therapies. The primary end-point was time to progression. Results In the intent-to-treat population (N=499), the median time to progression was 6.1, 7.0, 7.6, and 9.1 months in patients treated with dexamethasone, and thalidomide 100, 200, and 400 mg/day, respectively; the difference between treatment groups was not statistically significant. In the per-protocol population (n=465), the median time to progression was 6.0, 7.0, 8.0, and 9.1 months, respectively.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Haematologica-the Hematology Journal

ISSN

0390-6078

e-ISSN

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Volume of the periodical

97

Issue of the periodical within the volume

5

Country of publishing house

IT - ITALY

Number of pages

8

Pages from-to

784-791

UT code for WoS article

000304669000027

EID of the result in the Scopus database

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