IB-MECA, an Adenosine A3 Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00063449" target="_blank" >RIV/00216224:14110/12:00063449 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/12:00440789

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

IB-MECA, an Adenosine A3 Receptor Agonist, Does Not Influence Survival of Lethally gamma-Irradiated Mice

Original language description

In our previous studies, IB-MECA, an adenosine A3 receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regeneration of suppressed hematopoiesis after irradiation with sublethal doses of gamma-rays when the drug was given in a postirradiation treatment regimen. This study was aimed at assessing the ability of IB-MECA to influence a 30-day survival of lethally irradiated mice. In a series of experiments, IB-MECA was administered following various lethal radiation doses in various numbers of drug doses and various administration routes. Though in some of these experiments a moderate increase in 30-day survival wasobserved in IB-MECA-treated mice, the differences in comparison with the controls were not significantly different.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

649-654

UT code for WoS article

000314138600011

EID of the result in the Scopus database

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