Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00049995" target="_blank" >RIV/00216224:14110/11:00049995 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.biopha.2011.04.033" target="_blank" >http://dx.doi.org/10.1016/j.biopha.2011.04.033</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2011.04.033" target="_blank" >10.1016/j.biopha.2011.04.033</a>

Result language

angličtina

Original language name

Inhibition of cyclooxygenase-2 promotes the stimulatory action of adenosine A3 receptor agonist on hematopoiesis in sublethally y-irradiated mice

Original language description

Mouse hematopoiesis, suppressed by a sublethal dose of ionizing radiation, was the target for combined therapy with a cyclooxygenase-2 (COX-2) inhibitor meloxicam and an adenosine A3 receptor agonist IB-MECA. The drugs were administered in an early postirradiation treatment regimen: meloxicam was given in a single dose 1 hour after irradiation, IB-MECA in two doses 24 and 48 hours after irradiation. Treatment-induced changes in several compartments of hematopoietic progenitor and precursor cells of thebone marrow were evaluated on day 3 after irradiation. Values of hematopoietic progenitor cells for granulocytes/macrophages and erythrocytes (GM-CFC and BFU-E, respectively), as well as those of proliferative granulocytic cells were found to be significantly higher in the mice treated with the drug combination in comparison to irradiated controls and attained the highest increase factors of 1.6, 1.6, and 2.6, respectively.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GA305%2F08%2F0158" target="_blank" >GA305/08/0158: Activation of adenosine receptors combined with cyclooxygenase inhibition in modulation of radiation-induced myelosuppression</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedicine & Pharmacotherapy

ISSN

0753-3322

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

6

Country of publishing house

IE - IRELAND

Number of pages

5

Pages from-to

427-431

UT code for WoS article

000296961900006

EID of the result in the Scopus database

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