Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075665" target="_blank" >RIV/00216224:14110/14:00075665 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/14:00427937

Result on the web

<a href="http://dx.doi.org/10.2478/s11535-014-0295-0" target="_blank" >http://dx.doi.org/10.2478/s11535-014-0295-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11535-014-0295-0" target="_blank" >10.2478/s11535-014-0295-0</a>

Result language

angličtina

Original language name

Combined pharmacological therapy of the acute radiation disease using a cyclooxygenase-2 inhibitor and an adenosine A(3) receptor agonist

Original language description

Combined approaches to the treatment of acute radiation disease are preferred to single-agent therapies due to proven or anticipated better outcomes comprising increased therapeutic efficacy and decreased incidence of undesirable side effects. Our studies on post-exposure treatment of mice irradiated by sublethal or lethal doses of ionizing radiation included testing the effectiveness of meloxicam, a cyclooxygenase-2 inhibitor, and IB-MECA, an adenosine A3 receptor agonist. The efficacy of meloxicam andIB-MECA to positively influence the progress of the acute radiation disease has been tested in situations of their combined administration with granulocyte colony-stimulating factor (G-CSF) or with each other. The results of our studies revealed a significantly improved regeneration of hematopoietic cell populations ranging from the bone marrow progenitor cells to mature blood cells following combined treatments.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/GAP303%2F11%2F0128" target="_blank" >GAP303/11/0128: Role of adenosine A3 receptor signaling in regulation of hematopoiesis: knowledge obtained from adenosine A3 receptor knock-out mice</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Central European Journal of Biology

ISSN

1895-104X

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

6

Country of publishing house

PL - POLAND

Number of pages

5

Pages from-to

642-646

UT code for WoS article

000333127400005

EID of the result in the Scopus database

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