Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00064861" target="_blank" >RIV/00216224:14110/12:00064861 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/12:#0000812
Result on the web
<a href="http://dx.doi.org/10.1155/2012/795739" target="_blank" >http://dx.doi.org/10.1155/2012/795739</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2012/795739" target="_blank" >10.1155/2012/795739</a>
Alternative languages
Result language
angličtina
Original language name
Matrix metalloproteinase 13 genotype in rs640198 polymorphism is associated with severe coronary artery disease
Original language description
Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity. The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmedby coronary angiography. Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman (R) assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (se
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10206" target="_blank" >NS10206: Association of polymorphisms in genes for matrix metalloproteinases, their inhibitors, ACE and ACE2 with central pulse pressure in cardiovascular patients</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
DISEASE MARKERS
ISSN
0278-0240
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
1
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
43-49
UT code for WoS article
000305391200005
EID of the result in the Scopus database
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