Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00066243" target="_blank" >RIV/00216224:14110/13:00066243 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/13:00060581
Result on the web
<a href="http://dx.doi.org/10.1177/1535370213480711" target="_blank" >http://dx.doi.org/10.1177/1535370213480711</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/1535370213480711" target="_blank" >10.1177/1535370213480711</a>
Alternative languages
Result language
angličtina
Original language name
Cell cycle regulation in human embryonic stem cells: links to adaptation to cell culture
Original language description
Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitorcells, regulation of cell fate decision is of paramount importance. It has been shown that human embryonic stem cells (hESCs) show unique cell cycle characteristics, such as short doubling time due to abbreviated G1 phase; these properties change with the onset of differentiation. This review summarizes the current understanding of cell cycle regulation in hESCs. We discuss cell cycle properties as well as regulatory machinery governing cell cycle progression of undifferentiated hESCs. Additionally, weprovide evidence that long-term culture of hESCs is accompanied by changes in cell cycle properties as well as configuration of several cell cycle regulatory molecules.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Experimental Biology and Medicine
ISSN
1535-3702
e-ISSN
—
Volume of the periodical
238
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
271-275
UT code for WoS article
000318188900003
EID of the result in the Scopus database
—