PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00067529" target="_blank" >RIV/00216224:14110/13:00067529 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3324/haematol.2011.057067" target="_blank" >http://dx.doi.org/10.3324/haematol.2011.057067</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2011.057067" target="_blank" >10.3324/haematol.2011.057067</a>

Result language
angličtina
Original language name
PML-RAR alpha co-operates with Sox4 in acute myeloid leukemia development in mice
Original language description
Acute promyelocytic leukemia is characterized by a chromosomal translocation involving the retinoic acid receptor alpha gene. To identify cooperating pathways to leukemogenesis we crossed MRP8-PML/RARA transgenic mice with BXH-2 mice, which harbor an endogenous murine leukemia virus that causes acute myeloid leukemia. Approximately half of leukemias that arose in this cross showed features of acute promyelocytic leukemia. We identified 22 proviral insertions sites in acute promyelocytic-like leukemias and focused our analysis on insertion at Sox4, a HMG box transcription factor. Using a transplant model, cooperation between PML-RARalpha and Sox4 was confirmed with increased penetrance and reduced latency of disease. Interestingly, karyotypic analysis revealed cytogenetic changes suggesting that the factors combined to initiate but not complete leukemic transformation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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