Immunogenomic analysis of insect bite hypersensitivity in a model horse population

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00067927" target="_blank" >RIV/00216224:14110/13:00067927 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/13:43871557 RIV/62157124:16810/13:43871557 RIV/00027162:_____/13:#0001054
Result on the web
<a href="http://dx.doi.org/10.1016/j.vetimm.2012.12.013" target="_blank" >http://dx.doi.org/10.1016/j.vetimm.2012.12.013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vetimm.2012.12.013" target="_blank" >10.1016/j.vetimm.2012.12.013</a>

Result language
angličtina
Original language name
Immunogenomic analysis of insect bite hypersensitivity in a model horse population
Original language description
Equine insect bite hypersensitivity (IBH) is a seasonal IgE-mediated dermatosis caused by bites of insects of the genus Culicoides. A familial predisposition for the disease has been shown but, except for the MHC, the genes involved have not been identified so far. An immunogenomic analysis of IBH was performed in a model population of Old Kladruby horses, all living in the same environment. Clinical signs of IBH were used as phenotypic manifestation of IBH. Furthermore, total serum IgE levels were determined in the sera of these horses and used as an independent phenotypic marker for the immunogenetic analysis. Single nucleotide polymorphisms (SNPs) in candidate immunity-related genes were used for association analyses. Genotypes composed of two to five genes encoding interferon gamma ? IFNG, transforming growth factor beta 1 ? TGFB1, Janus kinase 2 ? JAK2, thymic stromal lymphopoietin ? TSLP, and involucrin ? IVL were associated with IBH, indicating a role of the genes in the pathoge
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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