Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068267" target="_blank" >RIV/00216224:14110/13:00068267 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16170/13:43872318 RIV/62157124:16810/13:43872318 RIV/62156489:43210/13:00199369
Result on the web
<a href="http://dx.doi.org/10.1007/s11033-012-2408-z" target="_blank" >http://dx.doi.org/10.1007/s11033-012-2408-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11033-012-2408-z" target="_blank" >10.1007/s11033-012-2408-z</a>

Result language
angličtina
Original language name
Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses
Original language description
Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of insects. IBH is a multifactorial disease with contribution of genetic and environmental factors. Candidate gene association analysis of IBH was performed in a groupof 89 Icelandic horses all born in Iceland and imported to Europe. Horses were classified in IBH-affected and non-affected based on clinical signs and history of recurrent dermatitis, and on the results of an in vitro sulfidoleukotriene (sLT)-release assay with Culicoides nubeculosus and Simulium vittatum extract. Different genetic markers were tested for association with IBH by the Fisher's exact test. The effect of the major histocompatibility complex (MHC) gene region was studied by genotyping fivemicrosatellites spanning the MHC region (COR112, COR113, COR114, UM011 and UMN-JH34-2), and exon 2 polymorphisms of the class II Eqca-DRA gene. Associations with Eqca-DRA and COR113 were identified (p < 0.05).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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