Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068061" target="_blank" >RIV/00216224:14110/13:00068061 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/13:00060755
Result on the web
<a href="http://dx.doi.org/10.1007/978-94-007-5958-9_26" target="_blank" >http://dx.doi.org/10.1007/978-94-007-5958-9_26</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-94-007-5958-9_26" target="_blank" >10.1007/978-94-007-5958-9_26</a>

Result language
angličtina
Original language name
Formation of Secretory Senescent Cells in Prostate Tumors: The Role of Androgen Receptor Activity and Cell Cycle Regulation
Original language description
The induction of senescence in cancer cells is believed to be a potent mechanism of tumor suppression; however, senescent cells remain metabolically active and secrete a broad spectrum of factors, modulate the tissue microenvironment, and potentially promote tumorigenicity in neighboring malignant cells. Another important subpopulation of secretory cells modulating the prostate tissue microenvironment is represented by neuroendocrine cells. Interestingly, androgen deprivation therapy, a widely used treatment for advanced prostate cancer, induces both the emergence of neuroendocrine-like prostate cancer cells and the senescence-associated secretory phenotype in prostate cancer epithelial cells.
Czech name
—
Czech description
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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