Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F11%3A00054887" target="_blank" >RIV/00216224:14740/11:00054887 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/11:00366527 RIV/00027162:_____/11:#0000815 RIV/68081707:_____/11:00391589
Result on the web
<a href="http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf" target="_blank" >http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1593/neo.11182" target="_blank" >10.1593/neo.11182</a>

Result language
angličtina
Original language name
Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2
Original language description
Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We proposethat ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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