Efficient use of basic biochemical methods to prove the presence of monoclonal protein in the clinical diagnosis of malignant monoclonal gammopathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068551" target="_blank" >RIV/00216224:14110/13:00068551 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/13:#0002102
Result on the web
<a href="http://dx.doi.org/10.1515/cclm-2013-0090" target="_blank" >http://dx.doi.org/10.1515/cclm-2013-0090</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cclm-2013-0090" target="_blank" >10.1515/cclm-2013-0090</a>
Alternative languages
Result language
angličtina
Original language name
Efficient use of basic biochemical methods to prove the presence of monoclonal protein in the clinical diagnosis of malignant monoclonal gammopathy
Original language description
Background: This retrospective study evaluates the diagnostic sensitivity of biochemistry methods for the clinical diagnosis of malignant monoclonal gammopathy. In patients with renal insufficiency, renal reference interval as well as standard referenceinterval is used for evaluating the ratio of free light chains. Methods: We examined samples in 281 patients who were diagnosed with malignant monoclonal gammopathy. The samples were taken at baseline, prior to treatment. Serum and urine protein electrophoresis, serum and urine immunofixation electrophoresis (SIFE+UIFE) and levels of free light chains in serum (FLC) were investigated. Results: Combination of methods with the highest diagnostic sensitivity is the use of maximal number of tests (SIFE+ UIFE + FLC), which identified 98.6% of patients. The achieved results do not statistically significantly differ from the procedure recommended by the International Myeloma Working Group (IMWG) which omitts the urine testing (SIFE + FLC) and
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Chemistry and Laboratory Medicine
ISSN
1434-6621
e-ISSN
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Volume of the periodical
51
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
3
Pages from-to
"e243"-"e245"
UT code for WoS article
000324921300008
EID of the result in the Scopus database
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