Multiple qualitative and quantitative methods for free light chain analysis are necessary as first line tests for AL amyloidosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F16%3A00059782" target="_blank" >RIV/00023001:_____/16:00059782 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/16:43911626
Result on the web
<a href="http://www.degruyter.com/view/j/cclm.2016.54.issue-6/cclm-2015-0816/cclm-2015-0816.xml" target="_blank" >http://www.degruyter.com/view/j/cclm.2016.54.issue-6/cclm-2015-0816/cclm-2015-0816.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cclm-2015-0816" target="_blank" >10.1515/cclm-2015-0816</a>
Alternative languages
Result language
angličtina
Original language name
Multiple qualitative and quantitative methods for free light chain analysis are necessary as first line tests for AL amyloidosis
Original language description
The objective of this study was to demonstrate the necessity of using different methods for amyloidogenic light chain detection. Serum and urine agarose gel electrophoresis and immunofixation, as well as serum free light chain (FLC) immunoassay measurements, were evaluated in a patient with verified multiple myeloma and consequent AL amyloidosis confirmed by Congo red staining and immunofluorescence techniques. Conventional chemistry tests [serum and urine electrophoresis (SPE and UPE); serum and urine immunofixation (SIFE and UIFE)] were inconclusive. Only quantitative FLC immunoassay (serum free light chain immunoanalysis, SFLC) provided correct diagnostic information. A combination of gel-based SIFE and UIFE with more novel quantitative FLC immunoassays appears necessary when searching for monoclonal immunoglobulin light chain-related diseases.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NV15-27579A" target="_blank" >NV15-27579A: Monoclonal gammopathies in solid organ transplant recipients. Relationship between posttransplant immunosuppression and lymphoproliferative diseases.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical chemistry and laboratory medicine
ISSN
1434-6621
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
4
Pages from-to
981-984
UT code for WoS article
000375209900010
EID of the result in the Scopus database
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