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Hydroxyl radicals? production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068604" target="_blank" >RIV/00216224:14110/13:00068604 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.4149/gpb_2013016" target="_blank" >http://dx.doi.org/10.4149/gpb_2013016</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4149/gpb_2013016" target="_blank" >10.4149/gpb_2013016</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Hydroxyl radicals? production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart

  • Original language description

    Ischemic and reperfusion injury is a serious condition related to numerous biochemical and electrical abnormalities of the myocardium. It has been repeatedly studied in various animal models. In this study, the production of hydroxyl radicals and electrophysiological parameters were compared in three species. Rat, guinea pig and rabbit isolated hearts were perfused according to Langendorff under strictly identical conditions. The heart rate and arrhythmia were monitored during ischemia and reperfusion periods at defined time intervals; the production of hydroxyl radical was determined by HPLC as 2.5-dihydroxybenzoic acid (2.5-DHBA) formed by salicylic acid hydroxylation. Relationship between arrhythmias and production of 2.5-DHBA was studied. The inter-species differences were observed in timing of arrhythmias onset and their severity, and in the production of 2.5-DHBA in both ischemia and reperfusion.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    General Physiology and Biophysics

  • ISSN

    0231-5882

  • e-ISSN

  • Volume of the periodical

    32

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    8

  • Pages from-to

    221-228

  • UT code for WoS article

    000320092300008

  • EID of the result in the Scopus database