Hydroxyl radicals? production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068604" target="_blank" >RIV/00216224:14110/13:00068604 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4149/gpb_2013016" target="_blank" >http://dx.doi.org/10.4149/gpb_2013016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/gpb_2013016" target="_blank" >10.4149/gpb_2013016</a>
Alternative languages
Result language
angličtina
Original language name
Hydroxyl radicals? production and ECG parameters during ischemia and reperfusion in rat, guinea pig and rabbit isolated heart
Original language description
Ischemic and reperfusion injury is a serious condition related to numerous biochemical and electrical abnormalities of the myocardium. It has been repeatedly studied in various animal models. In this study, the production of hydroxyl radicals and electrophysiological parameters were compared in three species. Rat, guinea pig and rabbit isolated hearts were perfused according to Langendorff under strictly identical conditions. The heart rate and arrhythmia were monitored during ischemia and reperfusion periods at defined time intervals; the production of hydroxyl radical was determined by HPLC as 2.5-dihydroxybenzoic acid (2.5-DHBA) formed by salicylic acid hydroxylation. Relationship between arrhythmias and production of 2.5-DHBA was studied. The inter-species differences were observed in timing of arrhythmias onset and their severity, and in the production of 2.5-DHBA in both ischemia and reperfusion.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
General Physiology and Biophysics
ISSN
0231-5882
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
2
Country of publishing house
SK - SLOVAKIA
Number of pages
8
Pages from-to
221-228
UT code for WoS article
000320092300008
EID of the result in the Scopus database
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