Dosing of Tissue Plasminogen Activator Often Differs from 0.9 mg/kg, but Does Not Affect the Outcome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069038" target="_blank" >RIV/00216224:14110/13:00069038 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/13:00060584
Result on the web
<a href="http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2012.10.010" target="_blank" >http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2012.10.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2012.10.010" target="_blank" >10.1016/j.jstrokecerebrovasdis.2012.10.010</a>

Result language
angličtina
Original language name
Dosing of Tissue Plasminogen Activator Often Differs from 0.9 mg/kg, but Does Not Affect the Outcome
Original language description
Background: The safety and efficacy of low-and high-dose intravenous tissue plasminogen activator (t-PA) for the treatment of acute ischemic stroke are poorly understood. In this multicenter study, we examined the relationships between different doses oft-PA and outcome. Methods: Between 2006 and 2010, patients were enrolled if they were treated with t-PA on the basis of estimated body weight and on the subsequent availability of actual body weight. Based on the actual weight, patients were divided into lower (<0.85 mg/kg), standard (0.85-0.95 mg/kg), and higher (>0.95 mg/kg) t-PA dose groups. Differences in the outcomes of these groups were compared in terms of functional recovery (modified Rankin Scale [mRS] 0-1) at 3 months and the incidenceof parenchymal hemorrhages on follow-up computed tomographic scans. Results: This cohort study included 272 patients: 171 (63%) patients received the standard t-PAdose, 62 (23%) a lower dose, and 39 (14%) a higher dose.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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