Strong negative interference of ethamsylate (Dicynone (R)) in serum creatinine quantification via enzymatic assay using Trinder reaction
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069727" target="_blank" >RIV/00216224:14110/13:00069727 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/13:#0002079
Result on the web
<a href="http://dx.doi.org/10.3109/00365513.2013.794300" target="_blank" >http://dx.doi.org/10.3109/00365513.2013.794300</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/00365513.2013.794300" target="_blank" >10.3109/00365513.2013.794300</a>
Alternative languages
Result language
angličtina
Original language name
Strong negative interference of ethamsylate (Dicynone (R)) in serum creatinine quantification via enzymatic assay using Trinder reaction
Original language description
Background. With discrepancies encountered as early as the verification of enzymatic method for quantification of serum creatinine, our research pointed to a later confirmed interference caused by a compound called ethamsylate present in the commonly used antihemorrhagic drug Dicynone. Methods. We measured concentrations of creatinine of 10 patients with blood taken before and 15 minutes after the intravenous administration of a 500 mg dose of Dicynone. The creatinine concentration was determined usingJaffe method and enzymatic method that utilize Trinder reaction (Roche) in analyzer Cobas c 501 (Roche AG, Basel, Switzerland). We also monitored concentration of blood creatinine in three patients before and 15 minutes after application of Dicynone (500mg i.v.) and in the following 6th, 12th, 18th, and 24th hours. Results. We discovered a significant negative bias in creatinine results using enzymatic assay with Trinder reaction in blood taken 15 min after i.v.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
ISSN
0036-5513
e-ISSN
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Volume of the periodical
73
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
3
Pages from-to
449-451
UT code for WoS article
000323106700014
EID of the result in the Scopus database
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