Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069863" target="_blank" >RIV/00216224:14110/13:00069863 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/path.4212" target="_blank" >http://dx.doi.org/10.1002/path.4212</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/path.4212" target="_blank" >10.1002/path.4212</a>
Alternative languages
Result language
angličtina
Original language name
Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
Original language description
The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular disease subclassifiers that can explain this heterogeneity beyond current parameters (MSI, KRAS, BRAF). Attempts to fill this gap are emerging. The Cancer Genome Atlas (TGCA) reported two main CRC groups, based on the incidence and spectrum of mutated genes, and another paper reported an EMT expression signature defined subgroup. We performed a prior free analysis of CRC heterogeneity on 1113 CRC gene expression profiles and confronted our findings to established molecular determinants and clinical, histopathological and survival data. Unsupervised clustering based on gene modules allowed us to distinguish at least five different gene expression CRC subtypes, which we call surface crypt-like, lower crypt-like, CIMP-H-like, mesenchymal and mixed.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
JOURNAL OF PATHOLOGY
ISSN
0022-3417
e-ISSN
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Volume of the periodical
231
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
63-76
UT code for WoS article
000322761500008
EID of the result in the Scopus database
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