Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00070162" target="_blank" >RIV/00216224:14110/13:00070162 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/13:#0002225
Result on the web
<a href="http://dx.doi.org/10.1200/JCO.2012.48.5052" target="_blank" >http://dx.doi.org/10.1200/JCO.2012.48.5052</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1200/JCO.2012.48.5052" target="_blank" >10.1200/JCO.2012.48.5052</a>
Alternative languages
Result language
angličtina
Original language name
Subgroup-Specific Prognostic Implications of TP53 Mutation in Medulloblastoma
Original language description
Purpose Reports detailing the prognostic impact of TP53 mutations in medulloblastoma offer conflicting conclusions. We resolve this issue through the inclusion of molecular subgroup profiles. Patients and Methods We determined subgroup affiliation, TP53mutation status, and clinical outcome in a discovery cohort of 397 medulloblastomas. We subsequently validated our results on an independent cohort of 156 medulloblastomas. Results TP53 mutations are enriched in wingless (WNT; 16%) and sonic hedgehog (SHH; 21%) medulloblastomas and are virtually absent in subgroups 3 and 4 tumors (P < .001). Patients with SHH/7P53 mutant tumors are almost exclusively between ages 5 and 18 years, dramatically different from the general SHH distribution (P < .001).Children with SHH/TP53 mutant tumors harbor 56% germline TP53 mutations, which are not observed in children with WNT/7P53 mutant tumors.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Clinical Oncology
ISSN
0732-183X
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
23
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
2927-2935
UT code for WoS article
000330539300018
EID of the result in the Scopus database
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