WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078705" target="_blank" >RIV/00216224:14110/14:00078705 - isvavai.cz</a>

Alternative codes found

RIV/00209805:_____/14:#0000585

Result on the web

<a href="http://dx.doi.org/10.1186/s40478-014-0174-y" target="_blank" >http://dx.doi.org/10.1186/s40478-014-0174-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s40478-014-0174-y" target="_blank" >10.1186/s40478-014-0174-y</a>

Result language

angličtina

Original language name

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

Original language description

TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitizeTP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or mutant human medulloblastoma cell-lines and normal neural stem cells were used to test radioresistance of TP53 mutations and the radiosensitizing effect of WNT activation on tumors and the developing brain. Children with WNT/TP53 mutant medulloblastoma had higher 5-year survival than those with SHH/TP53 mutant tumours (100% and 36.6% ? 8.7%, respectively (p &lt; 0.001)). Introduction of TP53 mutation into medulloblastoma cells induced radioresistance (survival fractions at 2Gy (SF2) of 89% ? 2% vs. 57.4% ? 1.8% (p &lt; 0.01)).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neuropathologica Communications

ISSN

2051-5960

e-ISSN

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Volume of the periodical

2

Issue of the periodical within the volume

174

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

1-12

UT code for WoS article

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EID of the result in the Scopus database

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