The association between the expression of solute carrier transporters and the prognosis of pancreatic cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00071472" target="_blank" >RIV/00216224:14110/13:00071472 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/13:#0002129 RIV/00023001:_____/13:00058644 RIV/75010330:_____/13:00010098 RIV/00216208:11120/13:43907545 and 2 more
Result on the web
<a href="http://dx.doi.org/10.1007/s00280-013-2246-2" target="_blank" >http://dx.doi.org/10.1007/s00280-013-2246-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00280-013-2246-2" target="_blank" >10.1007/s00280-013-2246-2</a>
Alternative languages
Result language
angličtina
Original language name
The association between the expression of solute carrier transporters and the prognosis of pancreatic cancer
Original language description
The aim of this study was to investigate the prognostic significance of fourteen anticancer drug-relevant solute carrier transporters (SLCs) in pancreatic cancer in the context of clinical-pathological characteristics and the KRAS mutation status of tumors. Tumors and non-neoplastic pancreatic tissues were obtained from 32 histologically verified patients with pancreatic ductal adenocarcinoma. The transcript profile of SLCs was assessed using quantitative real-time PCR. KRAS mutations in exon 2 were assessed by high-resolution melting analysis and confirmed by sequencing. SLC22A3 and SLC22A18 were upregulated and SLC22A1, SLC22A2, SLC22A11, SLC28A1, SLC28A3 and SLC29A1 were downregulated when compared with non-neoplastic pancreatic tissues. Moreover, significantly lower levels of SLC22A1, SLC22A11 and SLC29A1 were found in tumors with angioinvasion. There was also a significantly higher transcript level of SLC28A1 in tumors with regional lymph nodes affected by metastasis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CANCER CHEMOTHERAPY AND PHARMACOLOGY
ISSN
0344-5704
e-ISSN
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Volume of the periodical
72
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
669-682
UT code for WoS article
000323653600019
EID of the result in the Scopus database
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