Differences in Transcript Levels of ABC Transporters Between Pancreatic Adenocarcinoma and Nonneoplastic Tissues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00072145" target="_blank" >RIV/00216224:14110/13:00072145 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/13:#0002204 RIV/00023001:_____/13:00058501 RIV/75010330:_____/13:00010093 RIV/00216208:11120/13:43907365 RIV/00098892:_____/13:#0000612
Result on the web
<a href="http://dx.doi.org/10.1097/MPA.0b013e318279b861" target="_blank" >http://dx.doi.org/10.1097/MPA.0b013e318279b861</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/MPA.0b013e318279b861" target="_blank" >10.1097/MPA.0b013e318279b861</a>
Alternative languages
Result language
angličtina
Original language name
Differences in Transcript Levels of ABC Transporters Between Pancreatic Adenocarcinoma and Nonneoplastic Tissues
Original language description
Objectives: The aim of this study was to evaluate transcript levels of all 49 human ATP-binding cassette transporters (ABCs) in one of the most drug-resistant cancers, namely, the pancreatic ductal adenocarcinoma (PDAC). Association of ABCs levels with clinical-pathologic characteristics and KRAS mutation status was followed as well. Methods: Tumors and adjacent nonneoplastic tissues were obtained from 32 histologically verified PDAC patients. The transcript profile of ABCs was assessed using quantitative real-time polymerase chain reaction with a relative standard curve. KRAS mutations in exon 2 were assessed by high-resolution melting analysis and sequencing. Results: Most ABCs were deregulated in PDAC and 10 ABCs were associated with clinical-pathologic characteristics. KRAS mutations did not change the global expression profile of ABCs. Conclusions: The expression of ABC transporters was significantly deregulated in PDAC tumors when compared to nonmalignant tissues.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP301%2F12%2F1734" target="_blank" >GAP301/12/1734: Analysis of role of genetic factors in pancreatic cancer risk and prognosis</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pancreas
ISSN
0885-3177
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
707-716
UT code for WoS article
000317655200022
EID of the result in the Scopus database
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