microRNAs in nociceptive circuits as predictors of future clinical applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00071637" target="_blank" >RIV/00216224:14110/13:00071637 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fnmol.2013.00033" target="_blank" >http://dx.doi.org/10.3389/fnmol.2013.00033</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fnmol.2013.00033" target="_blank" >10.3389/fnmol.2013.00033</a>
Alternative languages
Result language
angličtina
Original language name
microRNAs in nociceptive circuits as predictors of future clinical applications
Original language description
Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs - and microRNAs (miRNAs) in particular - regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—
Result continuities
Project
—
Continuities
R - Projekt Ramcoveho programu EK
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Molecular Neuroscience
ISSN
1662-5099
e-ISSN
—
Volume of the periodical
6
Issue of the periodical within the volume
art. 33
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
1-11
UT code for WoS article
—
EID of the result in the Scopus database
—