Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00072194" target="_blank" >RIV/00216224:14110/13:00072194 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/13:10140026 RIV/65269705:_____/13:#0002193 RIV/00179906:_____/13:10140026 RIV/00216208:11110/13:10140026 and 2 more
Result on the web
<a href="http://dx.doi.org/10.1093/annonc/mdt139" target="_blank" >http://dx.doi.org/10.1093/annonc/mdt139</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/annonc/mdt139" target="_blank" >10.1093/annonc/mdt139</a>

Result language
angličtina
Original language name
Central nervous system involvement in mantle cell lymphoma: clinical features, prognostic factors and outcomes from the European Mantle Cell Lymphoma Network
Original language description
Central nervous system (CNS) involvement in mantle cell lymphoma (MCL) is uncommon, and the manifestations and natural history are not well described. We present the data on 57 patients with MCL who developed CNS involvement, from a database of 1396 consecutively treated patients at 14 institutions. The crude incidence of CNS involvement was 4.1%, with 0.9% having CNS involvement at diagnosis. Blastoid histology, B-symptoms, elevated lactate dehydrogenase, Eastern Cooperative Group performance status >= 2 and a high Mantle Cell Lymphoma International Prognostic Index score were enriched in the cohort with CNS involvement, and the presence of >= 1 of these features defined a high-risk subset (an actuarial risk of CNS involvement 15% at 5 years) ina single-institution subset. The median time to CNS relapse was 15.2 months, and the median survival from time of CNS diagnosis was 3.7 months. The white blood cell count at diagnosis < 10.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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