Immunophenotyping in Multiple Myeloma and Others Monoclonal Gammopathies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00072809" target="_blank" >RIV/00216224:14110/13:00072809 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.5772/55938" target="_blank" >http://dx.doi.org/10.5772/55938</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/55938" target="_blank" >10.5772/55938</a>

Result language
angličtina
Original language name
Immunophenotyping in Multiple Myeloma and Others Monoclonal Gammopathies
Original language description
Clonal plasma cell disorders (PCD) including mostly monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) are characterised by expansion of abnormal (clonal) plasma cells (PCs) producing monoclonal protein (M-protein, MIG).Although multiparametric flow cytometry (MFC) allows identification and characterisation of these neoplastic PCs, this approach is used in routine diagnostics of monoclonal gammopathies (MGs) complementarily, mostly in unusual cases. The technological development of flow cytometry (FC) in connection with new findings reveal the need for MFC in clinical analysis of MGs. The main applications of immunophenotypisation in MGs are (1) differential diagnosis, (2) determining the risk of progression in MGUS and asymptomatic MM (aMM), (3) detection of minimal residual disease in treated patients with MM, and (4) analysis of prognostic and/or predictive markers.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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