EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00076830" target="_blank" >RIV/00216224:14110/13:00076830 - isvavai.cz</a>

Alternative codes found

RIV/61388998:_____/13:00437443

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

EFFECT OF ION CONCENTRATION CHANGES IN T-TUBULES ON INTRACELLULAR SIGNALS CONTROLLING MECHANICAL ACTIVITY IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Original language description

The transverse (t-) tubular system serves to bring electrical signals deep inside the muscle cells to control mechanical responses. Our preliminary mathematical model of human ventricular cardiomyocyte incorporating t-tubular system [1] was improved by introducing description of latest experimental data related to morphology of human t-tubules and to specific properties of ionic currents. To describe the ion diffusion within t-tubular lumen, we partitioned the t-tubule compartment into nine concentric cylindrical segments. Using the model, we studied the effect of activity-induced concentration changes in the t-tubules on Ca2+ entry into the cell and the intracellular Ca2+ transients controlling the strength of cellular contraction. The values of somecrucial parameters, unknown in human cardiomyocytes to date, were regarded as independent variables.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Engineering mechanics

ISSN

1802-1484

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

6

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

481-490

UT code for WoS article

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EID of the result in the Scopus database

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