ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00139960" target="_blank" >RIV/00216224:14110/24:00139960 - isvavai.cz</a>
Result on the web
<a href="https://www.engmech.cz/improc/2024/230.pdf" target="_blank" >https://www.engmech.cz/improc/2024/230.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
ROLE OF SUBMEMBRANE SPACES IN THE CONTROL OF TRANSMEMBRANE ION FLUX AND CELLULAR INOTROPIC STATE IN A MODEL OF HUMAN VENTRICULAR CARDIOMYOCYTE
Original language description
We have recently developed a model of human ventricular cardiomyocyte incorporating the t-tubular and surface submembrane spaces and restricted ion exchange between these spaces and cytosol. After incorporating the experimental finding that majority of Na+ -Ca2+ exchanger proteins are located at the t-tubular membrane of human ventricular cardiomyocytes, we explored the consequences of ion concentration changes in the submembrane spaces on the electrophysiological activity of these cells. Consistently with the experimental and modelling studies published so far, our model predicts an increased Ca2+ extrusion during the action potential. However, our model also predicts a significant reduction of Ca2+ extrusion throughout the diastole, which can ultimately lead to an increase of cellular inotropy.
Czech name
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Czech description
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Project
<a href="/en/project/NU22-02-00348" target="_blank" >NU22-02-00348: Functional assessment of genetic variants in clinically “true” cases of idiopathic ventricular fibrillation: in vitro and in silico modelling to reveal the arrhythmogenic mechanism</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
ENGINEERING MECHANICS: 30th INTERNATIONAL CONFERENCE May 14 – 16, 2024, Milovy, Czech Republic
ISBN
9788021462359
ISSN
1805-8248
e-ISSN
1805-8256
Number of pages
4
Pages from-to
230-233
Publisher name
Institute of Thermomechanics, Academy of Sciences of the Czech Republic
Place of publication
Prague
Event location
Milovy
Event date
May 14, 2024
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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