Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075188" target="_blank" >RIV/00216224:14110/14:00075188 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/14:43872059 RIV/65269705:_____/14:00061595 RIV/00843989:_____/14:E0104015
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejpb.2013.12.002" target="_blank" >http://dx.doi.org/10.1016/j.ejpb.2013.12.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejpb.2013.12.002" target="_blank" >10.1016/j.ejpb.2013.12.002</a>

Result language
angličtina
Original language name
Determination of dependencies among in vitro and in vivo properties of prepared mucoadhesive buccal films using multivariate data analysis
Original language description
Mucoadhesive films represent the most developed medical form of buccal application. Despite the intense focus on buccal film-based systems, there are no standardized methods for their evaluation, which limits the possibility of comparison of obtained data and evaluation of the significance of influence of formulation and process variables on properties of resulting films. The used principal component analysis, together with a partial least squares regression provided a unique insight into the effects ofin vitro parameters of mucoadhesive buccal films on their in vivo properties and into interdependencies among the studied variables. In the present study eight various mucoadhesive buccal films based on mucoadhesive polymers (carmellose, polyethylene oxide) were prepared using a solvent casting method or a method of impregnation, respectively. An ethylcellulose or hydrophobic blend of white beeswax and white petrolatum were used as a backing layer.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Project
<a href="/en/project/NT11396" target="_blank" >NT11396: Mucoadhesive patches intended to dressing of mucosal defects of the oral cavity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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