Cytogenetic Prognostication Within Medulloblastoma Subgroups
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00076105" target="_blank" >RIV/00216224:14110/14:00076105 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/14:00061546
Result on the web
<a href="http://dx.doi.org/10.1200/JCO.2013.50.9539" target="_blank" >http://dx.doi.org/10.1200/JCO.2013.50.9539</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1200/JCO.2013.50.9539" target="_blank" >10.1200/JCO.2013.50.9539</a>
Alternative languages
Result language
angličtina
Original language name
Cytogenetic Prognostication Within Medulloblastoma Subgroups
Original language description
Purpose Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication. Patients and Methods Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent insitu hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of clinical oncology
ISSN
0732-183X
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
886-896
UT code for WoS article
000335137900019
EID of the result in the Scopus database
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