Intertumoral Heterogeneity within Medulloblastoma Subgroups

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F17%3A00067531" target="_blank" >RIV/65269705:_____/17:00067531 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/17:00098842

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1535610817302015?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1535610817302015?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccell.2017.05.005" target="_blank" >10.1016/j.ccell.2017.05.005</a>

Result language

angličtina

Original language name

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Original language description

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/EE2.3.20.0183" target="_blank" >EE2.3.20.0183: Center of Experimental Biomedicine</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Cell

ISSN

1535-6108

e-ISSN

—

Volume of the periodical

31

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

24

Pages from-to

737-"+"

UT code for WoS article

000403074800005

EID of the result in the Scopus database

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