Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00076387" target="_blank" >RIV/00216224:14110/14:00076387 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/14:00061107 RIV/65269705:_____/14:00061107
Result on the web
<a href="http://dx.doi.org/10.3109/07420528.2014.921790" target="_blank" >http://dx.doi.org/10.3109/07420528.2014.921790</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/07420528.2014.921790" target="_blank" >10.3109/07420528.2014.921790</a>
Alternative languages
Result language
angličtina
Original language name
Period3 VNTR polymorphism influences the time-of-day pain onset of acute myocardial infarction with ST elevation
Original language description
It is well established that the incidence and infarct size in acute myocardial infarction (AMI) is subject to circadian variations. At the molecular level, circadian clocks in distinct cells, including cardiomyocytes, generate 24-h cycles of biochemicalprocesses. Possible imbalance or impairment in the cell clock mechanism may alter the cardiac metabolism and function and increase the susceptibility of cardiovascular diseases. One of the key components of the human clock system PERIOD3 (PER3) has beenrecently demonstrated to affect circadian expression of various genes in different tissues, including the heart. The variable number tandem repeat (VNTR) polymorphism (rs57875989) in gene Period3 (Per3) is related to multiple phenotypic parameters, including diurnal preference, sleep homeostasis, infection and cancer. The aim of our study was to investigate the effect of this polymorphism in AMI with ST elevation (STEMI).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chronobiology International
ISSN
0742-0528
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
878-890
UT code for WoS article
000341754000002
EID of the result in the Scopus database
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