Identification of Key Structural Characteristics of Schisandra chinensis Lignans Involved in P-Glycoprotein Inhibition
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00077244" target="_blank" >RIV/00216224:14110/14:00077244 - isvavai.cz</a>
Alternative codes found
RIV/62157124:16370/14:43872727
Result on the web
<a href="http://dx.doi.org/10.1021/np500521v" target="_blank" >http://dx.doi.org/10.1021/np500521v</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/np500521v" target="_blank" >10.1021/np500521v</a>
Alternative languages
Result language
angličtina
Original language name
Identification of Key Structural Characteristics of Schisandra chinensis Lignans Involved in P-Glycoprotein Inhibition
Original language description
The aim of the present study was to determine the structural requirements for dibenzocyclooctadiene lignans essential for P-glycoprotein inhibition. Altogether 15 structurally related lignans isolated from Schisandra chinensis or prepared by modificationof their backbone were investigated, including three pairs of enantiomers. P-Glycoprotein inhibition was quantified using a doxorubicin accumulation assay in human promyelotic leukemia HL60/MDR cells overexpressing P-glycoprotein. A preliminary quantitative structure-activity relationship analysis revealed three main structural features involved in P-glycoprotein inhibition: a 1,2,3-trimethoxy moiety, a 6-acyloxy group, and the absence of a 7-hydroxy group. The most effective inhibitors, (-)-gomisin N(1) and (+)-deoxyschizandrin [(+)-2], were selected for further evaluation of their effects.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Natural Products
ISSN
0163-3864
e-ISSN
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Volume of the periodical
77
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
2255-2263
UT code for WoS article
000343786100013
EID of the result in the Scopus database
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