BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00077285" target="_blank" >RIV/00216224:14110/14:00077285 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/14:00061000
Result on the web
<a href="http://dx.doi.org/10.1016/j.yjmcc.2014.01.006" target="_blank" >http://dx.doi.org/10.1016/j.yjmcc.2014.01.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.yjmcc.2014.01.006" target="_blank" >10.1016/j.yjmcc.2014.01.006</a>

Result language
angličtina
Original language name
BDNF secretion by human pulmonary artery endothelial cells in response to hypoxia
Original language description
Within human pulmonary artery, neurotrophin growth factors [NTs; e.g. brain-derived neurotrophic factor (BDNF)] and their high-affinity receptors (tropomyosin-related kinase; Trk) and low-affinity receptors p75 neurotrophin receptor (p75NTR) have been reported, but their functional role is incompletely understood. We tested the hypothesis that BDNF is produced by human pulmonary artery endothelial cells (PAECs). In the context of hypoxia as a risk factor for pulmonary hypertension, we examined the effect of hypoxia on BDNF secretion and consequent autocrine effects on pulmonary endothelium. Initial ELISA analysis of circulating BDNF in 30 healthy human volunteers showed that 72 h exposure to high altitude (similar to 11,000 ft, alveolar PO2 = 100 mm Hg) results in higher BDNF compared to samples taken at sea level. Separately, in human PAECs exposed for 24 h to normoxia vs. hypoxia (1-3% O-2), ELISA of extracellular media showed increased BDNF levels.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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