Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F17%3A00478388" target="_blank" >RIV/68378271:_____/17:00478388 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4103/1673-5374.208546" target="_blank" >http://dx.doi.org/10.4103/1673-5374.208546</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4103/1673-5374.208546" target="_blank" >10.4103/1673-5374.208546</a>

Result language
angličtina
Original language name
Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair
Original language description
Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor (BDNF) and its high-affinity tropomyosin-related kinase receptor (TrkB) present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB (cAMP response element-binding protein) has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10305 - Fluids and plasma physics (including surface physics)

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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