Multicompartment lipid nanocarriers for targeting of cells expressing brain receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F12%3A00382205" target="_blank" >RIV/61389013:_____/12:00382205 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Multicompartment lipid nanocarriers for targeting of cells expressing brain receptors
Original language description
Neurotrophic factors, such as the brain-derived neurotrophic factor (BDNF), are essential for the development and survival of human neurons. Their encapsulation in carrier lipid systems is anticipated to overcome the problems resulting from the pharmacokinetics of peptides in the cerebral circulation. Lipid nanocarriers containing an omega-3 polyunsaturated fatty acid, should trigger the BDNF activity. The purpose of this study is to design and characterize self-assembled lipid systems suitable for encapsulation and potentialization of neurotrophic peptide activity and study of multicompartment liquid crystalline formulations in vitro on a human neuronal cell line expressing BDNF receptors. Sterically stabilized nanodispersed lipid systems are preparedfrom a PEGylated (polyethylene glycol) liquid crystalline phase in excess water. Such lipid nanovectors are of ongoing interest due to their biocompatible compositions and the relatively low energy input required for their manufacture.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Self-assembled supramolecular architectures: Lyotropic liquid crystals
ISBN
978-0-470-28175-8
Number of pages of the result
37
Pages from-to
319-355
Number of pages of the book
396
Publisher name
John Wiley & Sons
Place of publication
Hoboken
UT code for WoS chapter
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