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Multicompartment lipid nanocarriers for targeting of cells expressing brain receptors

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F12%3A00382205" target="_blank" >RIV/61389013:_____/12:00382205 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Multicompartment lipid nanocarriers for targeting of cells expressing brain receptors

  • Original language description

    Neurotrophic factors, such as the brain-derived neurotrophic factor (BDNF), are essential for the development and survival of human neurons. Their encapsulation in carrier lipid systems is anticipated to overcome the problems resulting from the pharmacokinetics of peptides in the cerebral circulation. Lipid nanocarriers containing an omega-3 polyunsaturated fatty acid, should trigger the BDNF activity. The purpose of this study is to design and characterize self-assembled lipid systems suitable for encapsulation and potentialization of neurotrophic peptide activity and study of multicompartment liquid crystalline formulations in vitro on a human neuronal cell line expressing BDNF receptors. Sterically stabilized nanodispersed lipid systems are preparedfrom a PEGylated (polyethylene glycol) liquid crystalline phase in excess water. Such lipid nanovectors are of ongoing interest due to their biocompatible compositions and the relatively low energy input required for their manufacture.

  • Czech name

  • Czech description

Classification

  • Type

    C - Chapter in a specialist book

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Book/collection name

    Self-assembled supramolecular architectures: Lyotropic liquid crystals

  • ISBN

    978-0-470-28175-8

  • Number of pages of the result

    37

  • Pages from-to

    319-355

  • Number of pages of the book

    396

  • Publisher name

    John Wiley & Sons

  • Place of publication

    Hoboken

  • UT code for WoS chapter