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Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F22%3A00560559" target="_blank" >RIV/68378271:_____/22:00560559 - isvavai.cz</a>

  • Result on the web

    <a href="https://hdl.handle.net/11104/0333429" target="_blank" >https://hdl.handle.net/11104/0333429</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.smaim.2022.03.001" target="_blank" >10.1016/j.smaim.2022.03.001</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Liquid crystalline lipid nanoparticles for combined delivery of curcumin, fish oil and BDNF: In vitro neuroprotective potential in a cellular model of tunicamycin-induced endoplasmic reticulum stress

  • Original language description

    We develop multidrug-loaded cubosome and spongosome lipid nanoparticles for targeting of endoplasmic reticulum stress as a potential emerging therapeutic strategy against neuronal degeneration. The multicompartment organization of the liquid crystalline nanoparticles (LCNPs), fabricated by self-assembly, was characterized by cryogenic transmission electron microscopy (cryo-TEM) and small-angle X-ray scattering (SAXS). Monoolein-based cubosome and spongosome LCNPs co-encapsulated the natural plant-derived antioxidant curcumin, fish oil rich in ω-3 polyunsaturated fatty acids (PUFA), and the neurotrophin brain-derived neurotrophic factor (BDNF), which is of vital need for neurogenesis. The neuroprotective properties of the nanoparticles were in vitro investigated in a cellular model of tunicamycin-induced endoplasmic reticulum (ER) stress using differentiated human neuroblastoma SH-SY5Y cells deprieved from serum.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database

  • CEP classification

  • OECD FORD branch

    10610 - Biophysics

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Smart Materials in Medicine

  • ISSN

    2590-1834

  • e-ISSN

    2590-1834

  • Volume of the periodical

    3

  • Issue of the periodical within the volume

    Jan

  • Country of publishing house

    CN - CHINA

  • Number of pages

    15

  • Pages from-to

    274-288

  • UT code for WoS article

  • EID of the result in the Scopus database

    2-s2.0-85126904679