Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078130" target="_blank" >RIV/00216224:14110/14:00078130 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1158/2159-8290.CD-14-0001" target="_blank" >http://dx.doi.org/10.1158/2159-8290.CD-14-0001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1158/2159-8290.CD-14-0001" target="_blank" >10.1158/2159-8290.CD-14-0001</a>
Alternative languages
Result language
angličtina
Original language name
Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
Original language description
Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical outcomes and are being used for preclinical drug evaluation, biomarker identification, biologic studies, and personalized medicine strategies. This article summarizes the current state of the art in this field, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and introduces a European consortium of PDX models. Significance: PDX models are increasingly used in translational cancer research. These models are useful for drug screening, biomarker development, and the preclinical evaluation of personalized medicine strategies.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Discovery
ISSN
2159-8274
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
998-1013
UT code for WoS article
000343121400023
EID of the result in the Scopus database
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