Why and how to spare the hippocampus during brain radiotherapy: the developing role of hippocampal avoidance in cranial radiotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078354" target="_blank" >RIV/00216224:14110/14:00078354 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/14:00061130

Result on the web

<a href="http://dx.doi.org/10.1186/1748-717X-9-139" target="_blank" >http://dx.doi.org/10.1186/1748-717X-9-139</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1748-717X-9-139" target="_blank" >10.1186/1748-717X-9-139</a>

Result language

angličtina

Original language name

Why and how to spare the hippocampus during brain radiotherapy: the developing role of hippocampal avoidance in cranial radiotherapy

Original language description

The goal of this review is to summarize the rationale for and feasibility of hippocampal sparing techniques during brain irradiation. Radiotherapy is the most effective non-surgical treatment of brain tumors and with the improvement in overall survival for these patients over the last few decades, there is an effort to minimize potential adverse effects leading to possible worsening in quality of life, especially worsening of neurocognitive function. The hippocampus and associated limbic system have long been known to be important in memory formation and pre-clinical models show loss of hippocampal stem cells with radiation as well as changes in architecture and function of mature neurons. Cognitive outcomes in clinical studies are beginning to provideevidence of cognitive effects associated with hippocampal dose and the cognitive benefits of hippocampal sparing.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation Oncology

ISSN

1748-717X

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

139

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

1-10

UT code for WoS article

000338674700001

EID of the result in the Scopus database

—