The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00079025" target="_blank" >RIV/00216224:14110/14:00079025 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/14:00441260 RIV/00159816:_____/14:00061063 RIV/61989592:15110/14:33163276 RIV/68081707:_____/14:00506380

Result on the web

<a href="http://dx.doi.org/10.1186/1476-4598-13-113" target="_blank" >http://dx.doi.org/10.1186/1476-4598-13-113</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1476-4598-13-113" target="_blank" >10.1186/1476-4598-13-113</a>

Result language

angličtina

Original language name

The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells

Original language description

Background: Tumor heterogeneity and the plasticity of cancer cells present challenges for effective clinical diagnosis and therapy. Such challenges are epitomized by neuroendocrine transdifferentiation (NED) and the emergence of neuroendocrine-like cancer cells in prostate tumors. This phenomenon frequently arises from androgen-depleted prostate adenocarcinoma and is associated with the development of castration-resistant prostate cancer and poor prognosis.Results: In this study, we showed that NED wasevoked in both androgen receptor (AR)-positive and AR-negative prostate epithelial cell lines by growing the cells to a high density. Androgen depletion and high-density cultivation were both associated with cell cycle arrest and deregulated expression of several cell cycle regulators, such as p27Kip1, members of the cyclin D protein family, and Cdk2. Dual inhibition of Cdk1 and Cdk2 using pharmacological inhibitor or RNAi led to modulation of the cell cycle and promotion of NED.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Molecular Cancer

ISSN

1476-4598

e-ISSN

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Volume of the periodical

13

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

1-16

UT code for WoS article

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EID of the result in the Scopus database

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