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The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00079025" target="_blank" >RIV/00216224:14110/14:00079025 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/14:00441260 RIV/00159816:_____/14:00061063 RIV/61989592:15110/14:33163276 RIV/68081707:_____/14:00506380

  • Result on the web

    <a href="http://dx.doi.org/10.1186/1476-4598-13-113" target="_blank" >http://dx.doi.org/10.1186/1476-4598-13-113</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/1476-4598-13-113" target="_blank" >10.1186/1476-4598-13-113</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells

  • Original language description

    Background: Tumor heterogeneity and the plasticity of cancer cells present challenges for effective clinical diagnosis and therapy. Such challenges are epitomized by neuroendocrine transdifferentiation (NED) and the emergence of neuroendocrine-like cancer cells in prostate tumors. This phenomenon frequently arises from androgen-depleted prostate adenocarcinoma and is associated with the development of castration-resistant prostate cancer and poor prognosis.Results: In this study, we showed that NED wasevoked in both androgen receptor (AR)-positive and AR-negative prostate epithelial cell lines by growing the cells to a high density. Androgen depletion and high-density cultivation were both associated with cell cycle arrest and deregulated expression of several cell cycle regulators, such as p27Kip1, members of the cyclin D protein family, and Cdk2. Dual inhibition of Cdk1 and Cdk2 using pharmacological inhibitor or RNAi led to modulation of the cell cycle and promotion of NED.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Molecular Cancer

  • ISSN

    1476-4598

  • e-ISSN

  • Volume of the periodical

    13

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    16

  • Pages from-to

    1-16

  • UT code for WoS article

  • EID of the result in the Scopus database