Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082099" target="_blank" >RIV/00216224:14110/15:00082099 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/15:00061496

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2014.043" target="_blank" >http://dx.doi.org/10.5507/bp.2014.043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2014.043" target="_blank" >10.5507/bp.2014.043</a>

Result language

angličtina

Original language name

Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels

Original language description

Aims. The aim of this study was to investigate the relationship between selected symptoms of chronic heart failure (myocardial infarction, plasma cholesterol level) and single nucleotide polymorphisms (SNPs) in the FAAH and CNR1 genes. Methods. A case ?control study involving 155 patients with chronic heart failure and 169 age- and sex-matched healthy subjects. We detected SNPs 385 C/A (rs324420) in the FAAH and 1359 G/A (rs1049353) in the CNR1 genes using the polymerase chain reaction and restrictionanalysis. Genotype and allele frequencies were compared between patients and controls as well as between patients with and without myocardial infarction. Results. No significant differences in genotype or allelic frequencies between patients and controlswere found (P &gt; 0.05). Carriers of the FAAH A allele had a 2.37-fold increase in the risk of myocardial infarction (odds ratio 2.37, 95% confidence interval 1.36-6.93, P = 0.01).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

159

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

535-539

UT code for WoS article

000366566700004

EID of the result in the Scopus database

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