The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F05%3A00100007" target="_blank" >RIV/00843989:_____/05:00100007 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
The MCP-1-2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population
Original language description
Monocyte chemoattractant protein (MCP)-1 is the key chemokine in the process of atheroslerotic vascular inflammation. Examining already reported association between coronary artery disease (CAD) and the SNP A/G in the MCP-1 gene (position -2518), 139 Czech patients with CAD manifested as myocardial infarction (MI) and 359 unrelated healthy control (C) subjects were genotyped by PCR-SSP. Genotype and allele frequencies were not different in MI and C groups (allele G: MI, 20.5%; C, 23.8%, OR = 0.8, P > 0.05). No differences were detected when the patients were subdivided based on sex or the age of MI first occurrence. Further, no relationship was observed between circulating MCP-1 levels and carriage of the G allele. The data do not support a role for the MCP-1 -2518 single nucleotide polymorphism in susceptibility to CAD manifested by myocardial infarction
Czech name
V české populaci není polymorfismus MCP-1-2518 (A/G) asociován s infarktem myokardu
Czech description
Protein MCP-1 je klíčovým chemokinem v procesu aterosklerotického zánětu. Studie ukazuje na vztah mezi kardiovaskulárním onemocněním a SNP A/G polymorfismem v genu

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/NI7308" target="_blank" >NI7308: Chemostatic cytokine MCP-1 and its receptors CCR2 and CCR5 in patients with atherosclerosis of coronary and peripheral arteries</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)