The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00002005" target="_blank" >RIV/61989592:15110/05:00002005 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The MCP-1 −2518 (A to G) single nucleotide polymorphism is not associated with myocardial infarction in the Czech population

Original language description

Monocyte chemoattractant protein (MCP)-1 is the keychemokine in the process of atheroslerotic vascularinflammation. Examining already reported associationbetween coronary artery disease (CAD) and the SNP A/Gin the MCP-1 gene (position &#8722;2518), 139 Czech patientswith CAD manifested as myocardial infarction (MI) and359 unrelated healthy control (C) subjects were genotypedby PCR-SSP. Genotype and allele frequencies werenot different in MI and C groups (allele G: MI, 20.5%; C,23.8%, OR = 0.8, P > 0.05). No differences were detectedwhen the patients were subdivided based on sex or theage of MI first occurrence. Further, no relationship wasobserved between circulating MCP-1 levels and carriageof the G allele. The data do not support a role for the MCP-1&#8722;2518 single nucleotide polymorphism in susceptibilityto CAD manifested by myocardial infarction.

Czech name

Jednonukleotidový polymorfismus MCP-1-2518 (A/G) nesouvisí s infarktem myokardu v české populaci

Czech description

Práce studuje souvislost polymorfismu genu pro chemokin MCP-1 (MCP-1-2518) ve vztahu k predispozici k aterosklerotickému postižení věnčitých tepen a infarktu myokardu. Asociační studie na 139 pacientech a 359 kontrolních jedincích nezjistila souvislost mezi uvedeným polymorfismem a infarktem myokardu v české populaci.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/NI7308" target="_blank" >NI7308: Chemostatic cytokine MCP-1 and its receptors CCR2 and CCR5 in patients with atherosclerosis of coronary and peripheral arteries</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Immunonegetics

ISSN

1744-3121

e-ISSN

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Volume of the periodical

32

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

4

Pages from-to

315-318

UT code for WoS article

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EID of the result in the Scopus database

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