The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10222091" target="_blank" >RIV/61989592:15110/11:10222091 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15310/11:10222091

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The BDNF Val66Met polymorphism is not associated with myocardial infarction in Czech patients.

Original language description

Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of coronary artery disease (CAD). BDNF Val66Met polymorphism has recently been associated with particular manifestation of CAD (unstable angina) in Chinese population. To further explore a possible role of this polymorphism as a genetic modifier in CAD we have investigated its association with myocardial infarction in the Czech population. BDNF Val66Met polymorphism was genotyped by realtime PCR (TaqMan) in 180 healthy unrelated control subjects and in 217 patients with myocardial infarction (MI) diagnosed according to the international (ESC) consensus. Genotype and allele frequencies of the BDNF Val66Met polymorphism did not differ between MI patients (frequency of BDNF 66Met allele: 18%, Met/Met genotype 4%) and control subjects (17%, 5%, p}0.05). Similarly, no association of BDNF Val66Met variant with MI was observed in the subanalysis according to the gender.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

<a href="/en/project/ME%20856" target="_blank" >ME 856: Polymorphism in genes for chemotactic cytokines and their receptors in Slavonic patients with myocardial infarction</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytokine

ISSN

1043-4666

e-ISSN

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Volume of the periodical

53

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

2

Pages from-to

13-14

UT code for WoS article

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EID of the result in the Scopus database

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