Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00083535" target="_blank" >RIV/00216224:14110/15:00083535 - isvavai.cz</a>

Alternative codes found

RIV/00209805:_____/15:#0000625 RIV/65269705:_____/15:00063184

Result on the web

<a href="http://dx.doi.org/10.1016/j.ccell.2015.04.002" target="_blank" >http://dx.doi.org/10.1016/j.ccell.2015.04.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ccell.2015.04.002" target="_blank" >10.1016/j.ccell.2015.04.002</a>

Result language

angličtina

Original language name

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

Original language description

Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classificationand thus might serve as a basis for the next World Health Organization classification of CNS tumors.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Cell

ISSN

1535-6108

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

728-743

UT code for WoS article

000354287300013

EID of the result in the Scopus database

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